Hydrochloric Acid → HCID 68610538, compound

Participants

Reaction Steps

To a solution of 3-[1-[5-[(2(S)-pyrrolidinyl)methoxy]-3-pyridyl]-3(R)-pyrrolidinyl]-1-propanol (120 mg, 0.39 mmol) in methanol (0.3 mL) was added 2N hydrochloric acid (0.64 mL, 3.3 equiv.) under N2. The reaction mixture was stirred for 4 h at room temperature. After evaporation in vacuo, the residue was diluted with water (12 mL) and lyophilized. The lyophilization process was repeated three times to obtain the hydrochloride (150 mg) as a light-yellow solid. 1H NMR (D2O, 300 MHz) δ 7.56 (s, 1H), 7.53 (s, 1H), 6.95 (s, 1H), 4.44 (d, 1H, J=10.5 Hz), 4.24 (t, 1H, J=8.1 Hz), 4.06-4.04 (m, 1H), 3.57-3.26 (m, 7H), 2.92 (t, 1H, J=8.7 Hz, 1H), 2.32-1.98 (m, 5H), 1.97-1.83 (m, 1H), 1.68-1.54 (m, 5H). LC-MS (ESI) m/z 306 (M+H+). Anal. Calcd. for C17H27N3O2.2.3HCl.1.0H2O: C, 50.13; H, 7.75; N, 10.32. Found: C, 50.15; H, 7.85; N, 10.20.

Provenance & Evidence