Hydrochloric Acid → 2-{4-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-7-oxo-[1,4]diazepan-1-yl}-succinic acid 1-methyl ester

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Reaction Steps

A solution of 0.30 g (0.60 mmol) of) 2-{4-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-7-oxo-[1,4]diazepan-1-yl}-succinic acid 4-tert-butyl ester 1-methyl ester in 1.2 ml of dioxane was cooled down to ˜6° C. and 1.50 ml (6.01 mmol) of hydrochloric acid 4M in dioxane, then 1 drop of water were added and stirring was continued overnight at RT. The solution was evaporated, dissolved in acetonitrile and evaporated (2×) to give the titled compound in quant. yield as yellow oil. MS: 441.2 (M−H−, 2Cl).

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