HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → (S)-4-((S)-3-Carboxy-2-hydroxy-propyl)-2-methyl-3-oxo-piperazine-1-carboxylic acid benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | (S)-4-((S)-2-Hydroxy-3-methoxycarbonyl-propyl)-2-methyl-3-oxo-piperazine-1-carboxylic acid benzyl ester | HCID 67074026 | — |
| Product | (S)-4-((S)-3-Carboxy-2-hydroxy-propyl)-2-methyl-3-oxo-piperazine-1-carboxylic acid benzyl ester | HCID 67074047 | 81% |
Reaction Steps
In analogy to the procedure described in Example 23B, (S)-4-((S)-2-hydroxy-3-methoxycarbonyl-propyl)-2-methyl-3-oxo-piperazine-1-carboxylic acid benzyl ester and 1 M aq. lithium hydroxide solution gave after extraction with EtOAc and precipitation (dichloromethane/n-pentane) the titled compound in 81% yield as light yellow waxy solid. MS: 351.15 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445674B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-ae12123cbb854d96a8a5c02f7238977b |
| Source note | uspto-grants-2013_05 |