HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl bromoacetate → {4-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-7-oxo-[1,4]diazepan-1-yl}-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | 1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one | HCID 62044921 | — |
| Product | {4-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-7-oxo-[1,4]diazepan-1-yl}-acetic acid ethyl ester | HCID 67074624 | 51% |
Reaction Steps
In analogy to the procedure described in intermediate 5B, 1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one (intermediate 5A) and ethyl bromoacetate gave, after purification on a SiO2-column (n-heptane/EtOAc 1:2 to 100% EtOAc), the titled compound in 51% yield as white foam. MS: 399.1 (MH+, 2Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445674B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-68ed1951c118449d8ba516d8ba838332 |
| Source note | uspto-grants-2013_05 |