HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → {4-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-7-oxo-[1,4]diazepan-1-yl}-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | {4-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-7-oxo-[1,4]diazepan-1-yl}-acetic acid ethyl ester | HCID 67074624 | — |
| Product | {4-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-7-oxo-[1,4]diazepan-1-yl}-acetic acid | HCID 67074076 | — |
Reaction Steps
In analogy to the procedure described in intermediate 5C, {4-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-7-oxo-[1,4]diazepan-1-yl}-acetic acid ethyl ester and 1 M aq. lithium hydroxide solution gave after acidification with aqueous 10% KHSO4, filtration and washing with water the title compound in quantitative yield as white solid. MS: 371.0 (MH+, 2Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445674B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-ab7820f57d0f442abbf0d5d53bfda2fe |
| Source note | uspto-grants-2013_05 |