Hydrochloric Acid → HCID 86652693, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.20 g (0.78 mmol) of 4-((S)-3-Methyl-2-oxo-piperazin-1-yl)-butyric acid tert-butyl ester, 0.1 eq. of HCl, 0.53 g (1.56 mmol) of 4-iodo-1,2-bis-trifluoromethyl-benzene (WO2007034282), 0.04 g (0.078 mmol) bis(tri-tert-butylphosphine)palladium(0) and 0.33 g (1.56 mmol) tripotassium phosphate in 2 ml of 1,2-dimethoxyethane was degased and heated at 120° C. for 2 h under microwave irradiation, diluted with dichloromethane, filtered and evaporated. Purification on a SiO2-column (1-propanol in n-heptane 2 to 5%), gave the titled compound in 35% yield as light brown oil. MS: 413.13 (M[-C4H8]H+).

Provenance & Evidence