Lithium borohydride → HCID 67074127, compound

Participants

Reaction Steps

In analogy to the procedure described in example 6B, 2-{4-[(E)-3-(3-chloro-phenyl)-acryloyl]-7-oxo-[1,4]diazepan-1-yl}-succinic acid 4-tert-butyl ester 1-methyl ester (intermediate 8C) and 2 eq. of LiBH4 gave, after only 1 night of stirring and purification on a SiO2-column (dichloromethane/MeOH 98:2-95:5), the titled compound in 84% yield as white foam. MS: 436.9 (MH+, 1Cl).

Provenance & Evidence