Lithium Hydroxide → HCID 67087035, compound

Participants

Reaction Steps

A solution of 2.01 g (4.40 mmol) of 4-((S)-3-benzyloxy-1-methoxycarbonyl-propyl)-5-oxo-[1,4]diazepane-1-carboxylic acid benzyl ester in 12 ml of tetrahydrofuran/methanol (1:1) was treated at 0° C. with 4.43 ml (4.40 mmol) of 1 M aq. lithium hydroxide solution, and kept 3 h at this temperature. The reaction was evaporated, dissolved in acetonitrile and evaporated again (3×) to give 1.94 g (98%) of the titled compound as light yellow foam. MS: 439.2 (M−H−).

Provenance & Evidence