Hydrochloric Acid → HCID 67074641, compound

Participants

Reaction Steps

A solution of 1.85 g (4.00 mmol) 4-((R)-3-benzyloxy-1-dimethylcarbamoyl-propyl)-5-oxo-[1,4]diazepane-1-carboxylic acid benzyl ester in 57 ml of methanol was treated with a solution of 3.96 ml of 1 M aq. hydrochloric acid solution and 0.20 g of Pd/C (10%) and was stirred over H2-atmosphere for 16 h. After filtration, the solution was evaporated, dissolved in methanol and evaporated (3×), followed with dichloromethane and evaporated (3×) under reduced pressure to yield 1.10 g (99%) of the titled compound as a white foam. MS: 244.1 (MH+).

Provenance & Evidence