HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-isocyanato-1-(trifluoromethyl)benzene → HCID 67074627, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-isocyanato-1-(trifluoromethyl)benzene | HCID 14368497 | — |
| Reactant | HCID 67074048 | HCID 67074048 | — |
| Product | HCID 67074627 | HCID 67074627 | 36% |
Reaction Steps
In analogy to the procedure described in Example 30, (S)—(S)-1-[2-hydroxy-4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-3-methyl-piperazin-2-one (intermediate 25) and 1.2 eq. of 2-chloro-4-isocyanato-1-trifluoromethyl-benzene (intermediate 16) gave the titled compound in 36% yield as white powder. MS: 547.19 (MH+, Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445674B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-4dd5abca3a7d450998a397e1b1ff4fdf |
| Source note | uspto-grants-2013_05 |