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HRID2095577

反应详情

EQUATION

反应方程式

HRID 2095577 的结构方程式

REACTANTS

反应物

2
结构：O[C@@H]1CNCCC12CC2
HCID44541813

未命名化合物

结构：C[C@@H]1C(=O)N(CCCC(=O)O)CCN1c1ccc(Cl)c(Cl)c1
HCID67074560

未命名化合物

PRODUCTS

生成物

1
结构：Cl.O[C@@H]1CNCCC12CC2
HCID44541812

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described in Example 15, 4-[(R)-4-(3,4-dichloro-phenyl)-3-methyl-2-oxo-piperazin-1-yl]-butyric acid (62% ee) and 1.1 eq. of (S)-6-aza-spiro[2.5]octan-4-ol; hydrochloride (intermediate 2) gave after precipitation (Et2O/n-pentane) the titled compound in 77% yield as light yellow foam. MS: 454.16 (MH+, 2Cl).