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HRID2095578

反应详情

EQUATION

反应方程式

HRID 2095578 的结构方程式

REACTANTS

反应物

2
反应SMILES：O[C@@H]1CNCCC12CC2
HCID44541813

未命名化合物

反应SMILES：C[C@H]1C(=O)N(CCCC(=O)O)CCN1c1ccc(C(F)(F)F)c(Cl)c1
HCID67075029

未命名化合物

PRODUCTS

产物

1
反应SMILES：Cl.O[C@@H]1CNCCC12CC2
HCID44541812

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described in Example 15, 4-[(S)-4-(3-chloro-4-trifluoromethyl-phenyl)-3-methyl-2-oxo-piperazin-1-yl]-butyric acid (26% ee) and 1.1 eq. of (S)-6-aza-spiro[2.5]octan-4-ol; hydrochloride (intermediate 2) gave after precipitation (Et2O/n-pentane) the titled compound in 95% yield as light yellow foam. MS: 488.19 (MH+, Cl).