HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4S)-6-Azaspiro[2.5]octan-4-ol → (4S)-6-Azaspiro[2.5]octan-4-ol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4S)-6-Azaspiro[2.5]octan-4-ol | HCID 44541813 | — |
| Reactant | HCID 67074693 | HCID 67074693 | — |
| Product | (4S)-6-Azaspiro[2.5]octan-4-ol hydrochloride | HCID 44541812 | — |
Reaction Steps
In analogy to the procedure described in Example 15, 4-[(S)-4-(4-Chloro-3-trifluoromethoxy-phenyl)-3-methyl-2-oxo-piperazin-1-yl]-butyric acid (22% ee) and 1.1 eq. of (S)-6-aza-spiro[2.5]octan-4-ol; hydrochloride (intermediate 2) gave after precipitation (Et2O/n-pentane) the titled compound in 63% yield as light yellow foam. MS: 504.19 (MH+, Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445674B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-9cd8f0feab6446ddadd8b56b8129601a |
| Source note | uspto-grants-2013_05 |