Lithium hydroxide, monohydrate → HCID 58232143, compound

Participants

Reaction Steps

To 0.15 g (0.26 mmol) of (S)-4-(3,4-dichloro-phenylcarbamoyl)-1-[4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-5-methyl-6-oxo-piperazine-2-carboxylic acid methyl ester in 2 ml of MeOH was added 0.01 g (0.26 mmol) of lithium hydroxide monohydrate. The reaction was stirred for 16 h after which time Amberlite IR120 resin was added until the pH was 5 and the reaction filtered and concentrated to afford the titled compound in 73% yield, a 6:4 mixture of diasteriomers as a colorless gum. MS: 541.3 (MH+, 2Cl).

Provenance & Evidence