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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2095589Generated: October 31, 2026

(4S)-6-Azaspiro[2.5]octan-4-ol → (4S)-6-Azaspiro[2.5]octan-4-ol hydrochloride

https://huagongshe.com/reaction/2095589

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(4S)-6-Azaspiro[2.5]octan-4-olHCID 44541813—
ReactantHCID 67074570HCID 67074570—
Product(4S)-6-Azaspiro[2.5]octan-4-ol hydrochlorideHCID 44541812—
ProductHCID 58232085HCID 58232085—

Reaction Steps

In analogy to the procedure described for example 15, 4-[4-(3-chloro-4-trifluoromethoxy-phenyl)-7-oxo-[1,4]diazepan-1-yl]-butyric acid (intermediate 40) and (S)-6-aza-spiro[2.5]octan-4-ol; hydrochloride (intermediate 2) gave the title compound in 54% yield as light yellow oil. MS: 504.19 (MH+, Cl).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08445674B2
Source datasetuspto-grants-2013_05
ORD IDord-213be7eec3bf41b99ce294eb1aa3f62a
Source noteuspto-grants-2013_05