Hydrochloric Acid → HCID 86652698, compound

Participants

Reaction Steps

A solution of 0.47 g (0.8 mmol) of (S)-2-{2-[(2-tert-butoxycarbonyl-ethyl)-(3-chloro-4-trifluoromethyl-phenyl)-amino]-ethylamino}-5-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-5-oxo-pentanoic acid methyl ester in 2.2 ml of dioxan was cooled (10° C.), treated with 1.9 ml (7.6 mmol) of HCl solution (4 M in dioxane), 2 drops of water and stirred at RT for 22 h. The solution was evaporated, suspended in acetonitrile and evaporated (3×) to yield 0.47 g (92%) of the title compound as light yellow foam. MS (LC/MS): 564 (MH+, Cl).

Provenance & Evidence