HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium borohydride → HCID 52913249, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium borohydride | HCID 4148881 | — |
| Reactant | HCID 58232206 | HCID 58232206 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 52913249 | HCID 52913249 | 62% |
Reaction Steps
In analogy to the procedure described for intermediate 40C, (S)-2-[4-(3-Chloro-4-trifluoromethyl-phenyl)-7-oxo-[1,4]diazepan-1-yl]-5-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-5-oxo-pentanoic acid methyl ester (example 123) and LiBH4 (2 M in THF)/MeOH gave the title compound in 62% yield as yellow oil. MS: 518.20 (MH+, Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445674B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-64deebba43d249feb6791eab62752105 |
| Source note | uspto-grants-2013_05 |