HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4S)-6-Azaspiro[2.5]octan-4-ol → (4S)-6-Azaspiro[2.5]octan-4-ol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4S)-6-Azaspiro[2.5]octan-4-ol | HCID 44541813 | — |
| Reactant | HCID 67074307 | HCID 67074307 | — |
| Product | (4S)-6-Azaspiro[2.5]octan-4-ol hydrochloride | HCID 44541812 | — |
| Product | HCID 58232195 | HCID 58232195 | — |
Reaction Steps
In analogy to the procedure described for example 15, 4-[(R)-4-(4-chloro-3-trifluoromethyl-phenyl)-3-methyl-7-oxo-2,3,4,7-tetrahydro-[1,4]diazepin-1-yl]-butyric acid (46% ee) (intermediate 35) and (S)-6-aza-spiro[2.5]octan-4-ol; hydrochloride (intermediate 2) gave the title compound in 69% yield as light yellow oil. MS: 544.19 (M+HCOO−, Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445674B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-d5432005d33f4b378468096be011a619 |
| Source note | uspto-grants-2013_05 |