Lithium borohydride → HCID 52913367, compound

Participants

Reaction Steps

In analogy to the procedure described in Example 53, (S)-2-[(S)-4-(3,4-bis-trifluoromethyl-phenylcarbamoyl)-3-methyl-2-oxo-piperazin-1-yl]-5-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-5-oxo-pentanoic acid methyl ester (example 143) and LiBH4 (2 M in THF)/MeOH gave the titled compound in 79% yield as amorphous white solid. MS: 595.23 (MH+).

Provenance & Evidence