Lithium borohydride → HCID 67087124, compound

Participants

Reaction Steps

In analogy to the procedure described in example 53, (R)-2-[(S)-4-(3-chloro-4-trifluoromethyl-phenylcarbamoyl)-3-methyl-2-oxo-piperazin-1-yl]-5-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-5-oxo-pentanoic acid methyl ester (example 145) and LiBH4 (2 M in THF)/MeOH gave the titled compound in 66% yield as amorphous white solid. MS: 561.20 (MH+, 1Cl).

Provenance & Evidence