HCID 67074736, compound → HCID 67087051, compound

HRID 2095603Notes

Reaction equation

HRID 2095603 reaction equation
C(OC([N:11]1[CH2:16][C@@H:15]([C:17](=[O:19])[NH2:18])[N:14]([CH2:20][CH2:21][CH2:22][C:23]([N:25]2[CH2:32][CH2:31][C:28]3([CH2:30][CH2:29]3)[C@H:27]([OH:33])[CH2:26]2)=[O:24])[C:13](=[O:34])[C@@H:12]1[CH3:35])=O)C1C=CC=CC=1.[H][H]>[Pd]>[OH:33][C@@H:27]1[CH2:26][N:25]([C:23](=[O:24])[CH2:22][CH2:21][CH2:20][N:14]2[C:13](=[O:34])[C@H:12]([CH3:35])[NH:11][CH2:16][C@H:15]2[C:17]([NH2:18])=[O:19])[CH2:32][CH2:31][C:28]21[CH2:29][CH2:30]2

Participants

4

Reactant 2

HCID 67074736HCID 67074736, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 67087051HCID 67087051, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

In analogy to the procedure described in the first part of example 120 step E, (2S,5S)-5-carbamoyl-4-[4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid benzyl ester was treated with 10% palladium on charcoal and the reaction was stirred under 1 atmosphere of hydrogen affording the titled compound in quantitative yield as a colorless foam. MS: 353.4 (MH+).

Sources & evidence

ORD record
ord-3ed89eca59e648f2b071c4a5de2f7445
Source dataset
uspto-grants-2013_05
Patent number
US08445674B2

Reaction notes

Loading…