2-Chloro-4-isocyanato-1-(trifluoromethyl)benzene → HCID 52913369, compound

Participants

Reaction Steps

In analogy to the procedure described in the second part of example 120 step E, (2S,5S)-1-[4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-5-methyl-6-oxo-piperazine-2-carboxylic acid amide was reacted with 2-chloro-4-isocyanato-1-trifluoromethyl-benzene (intermediate 16) to give the titled compound in 88% yield as a colorless solid. MS: 574.3 (MH+, 1Cl).

Provenance & Evidence