2-Chloro-4-isocyanato-1-(trifluoromethyl)benzene → HCID 58232164, compound

Participants

Reaction Steps

In analogy to the procedure described in the example 120 step E, (2S,5R)-5-carbamoyl-4-[4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid benzyl ester (example 147 step B) was first deprotected using 10% palladium on charcoal and then subsequently reacted with 2-chloro-4-isocyanato-1-trifluoromethyl-benzene (intermediate 16) to give the titled compound in 73% yield as a colorless solid. MS: 574.3 (MH+, 1Cl).

Provenance & Evidence