Water → HCID 89131043, compound

Participants

Reaction Steps

To a solution of benzyl {2-fluoro-4-[(6-{[(4-methylphenyl)sulfonyl]amino}pyridin-3-yl)oxy]phenyl}carbamate (32.0 g, 63.1 mmol) in N,N-dimethylformamide (320 mL) were added N,N-diisopropylethylamine (14.3 mL, 82.0 mmol) and iodoacetamide (15.2 g, 82.0 mmol), and the mixture was stirred at room temperature for 24 hr. Water was added to the reaction mixture, and the mixture was extracted twice with ethyl acetate/tetrahydrofuran. The combined organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate and filtered. The solvent was evaporated under reduced pressure, and the residue was washed with hexane/ethyl acetate and collected by filtration to give the title compound (34.2 g, 96%).

Provenance & Evidence