反应详情

温度

50 °C

A suspension of N-(6-hydroxy-1,3-benzothiazol-2-yl)cyclopropanecarboxamide (1.17 g, 5.00 mmol), 1,2-difluoro-4-nitrobenzene (0.96 g, 6.00 mmol) and cesium carbonate (3.26 g, 10.0 mmol) in dimethyl sulfoxide (10 mL) was stirred at 50° C. for 5 hr. After cooling to room temperature, water was added to the reaction mixture, and the mixture was extracted 3 times with ethyl acetate/tetrahydrofuran. The organic layer was washed with water, dried over anhydrous sodium sulfate and filtered. The solvent was evaporated under reduced pressure, and the residue was washed with ethyl acetate and collected by filtration to give the title compound (1.22 g, 65%) as a pale-yellow solid.

1. temperatureAfter cooling to room temperature
2. extractionthe mixture was extracted 3 times with ethyl acetate/tetrahydrofuran
3. washThe organic layer was washed with water
4. dry with materialdried over anhydrous sodium sulfate
5. filtrationfiltered
6. customThe solvent was evaporated under reduced pressure
7. washthe residue was washed with ethyl acetate
8. filtrationcollected by filtration