Methanol → HCID 58158461, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 2-(4-fluorophenyl)-1-methyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate (1.6 g, 5.9 mmol) in tetrahydrofuran (6 mL)/methanol (5 mL) was added 4N aqueous sodium hydroxide solution (9 mL), and the mixture was stirred at 60° C. for 1 hr. Tetrahydrofuran and methanol were evaporated under reduced pressure. 6N Aqueous hydrochloric acid solution was added to the residue with stirring, and the precipitated solid was collected by filtration. The filtrate was washed with water and ethyl acetate/hexane (1/5), and dried under reduced pressure to give the title compound (1.1 g, 79%) as a white solid.

Provenance & Evidence