HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl (ethoxymethylene)malonate → ethyl 5-hydroxy-1-(2-methylphenyl)-1H-pyrazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | o-Tolylhydrazinium(1+) chloride | HCID 71554 | — |
| Solvent | Water | HCID 962 | — |
| Product | ethyl 5-hydroxy-1-(2-methylphenyl)-1H-pyrazole-4-carboxylate | HCID 10037547 | 87% |
Reaction Steps
In the same manner as in Reference Example 63 and using (2-methylphenyl)hydrazine•hydrochloride (5 g, 32 mmol), water (100 mL), potassium carbonate (9.7 g, 70 mmol) and diethyl ethoxymethylenemalonate (8.3 g, 38 mmol) as starting materials, the title compound (6.8 g, 87%) was obtained as a brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445509B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-fc04d8391d124aa6a198cb848ae4c526 |
| Source note | uspto-grants-2013_05 |