HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 1-methyl-2-(2-methylphenyl)-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | ethyl 1-methyl-2-(2-methylphenyl)-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate | HCID 58158463 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-methyl-2-(2-methylphenyl)-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid | HCID 58158594 | 40% |
Reaction Steps
In the same manner as in Reference Example 65 and using ethyl 1-methyl-2-(2-methylphenyl)-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate (2.1 g, 8.2 mmol), tetrahydrofuran (6 mL), methanol (4 mL) and 4N aqueous sodium hydroxide solution (9 mL) as starting materials, the title compound (750 mg, 40%) was obtained as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445509B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-a1affcaa4796436681ebc88bd541ff8e |
| Source note | uspto-grants-2013_05 |