Methyl triflate → HCID 58158617, compound

HRID 2095817Notes

Reaction equation

[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:13](=[O:14])[C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:11][NH:10]1.F[C:21](F)(F)S(OC)(=O)=O>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:13](=[O:14])[C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:11][N:10]1[CH3:21]

Participants

Reactant 2

HCID 9526Methyl triflate

HCID 58158459HCID 58158459, compound

Product 1

HCID 58158617HCID 58158617, compoundYield 65%

Procedure

In the same manner as in Reference Example 64 and using ethyl 2-(2,4-difluorophenyl)-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate (3.6 g, 13 mmol) and methyl trifluoromethanesulfonate (3 mL) as starting materials, the title compound (2.4 g, 65%) was obtained as a white solid.

Sources & evidence

ORD record: ord-53d206291d554d80a9cc6803a6a3cf5a
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08445509B2

Reaction notes

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