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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2095818Generated: November 1, 2026

Tetrahydrofuran → HCID 58158587, compound

https://huagongshe.com/reaction/2095818

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTetrahydrofuranHCID 8028—
ReactantSodium HydroxideHCID 14798—
ReactantHCID 58158617HCID 58158617—
SolventMethanolHCID 887—
ProductHCID 58158587HCID 5815858783%

Reaction Steps

In the same manner as in Reference Example 65 and using ethyl 2-(2,4-difluorophenyl)-1-methyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate (2.4 g, 8.7 mmol), tetrahydrofuran (6 mL), methanol (5 mL) and 4N aqueous sodium hydroxide solution (8 mL) as starting materials, the title compound (1.8 g, 83%) was obtained as a white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08445509B2
Source datasetuspto-grants-2013_05
ORD IDord-582f4a132a574738b735d95d9cd899b7
Source noteuspto-grants-2013_05