Methyl triflate → HCID 58158582, compound

HRID 2095820Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:13](=[O:14])[C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:11][NH:10]1.F[C:21](F)(F)S(OC)(=O)=O>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:13](=[O:14])[C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:11][N:10]1[CH3:21]

Participants

Reactant 2

HCID 9526Methyl triflate

HCID 58158589HCID 58158589, compound

Product 1

HCID 58158582HCID 58158582, compoundYield 66%

Procedure

In the same manner as in Reference Example 64 and using ethyl 2-(2-methoxyphenyl)-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate (3.6 g, 14 mmol) and methyl trifluoromethanesulfonate (3 mL) as starting materials, the title compound (2.5 g, 66%) was obtained as a pale-yellow solid.

Sources & evidence

ORD record: ord-a072c6e89f9f405d91ca92846303c2b0
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08445509B2

Reaction notes

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