Tetrahydrofuran → 5-ethyl-2-(4-fluorophenyl)-1-methyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid

Participants

Reaction Steps

In the same manner as in Reference Example 65 and using ethyl 5-ethyl-2-(4-fluorophenyl)-1-methyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate (1.9 g, 6.4 mmol), tetrahydrofuran (4 mL), methanol (4 mL) and 4N aqueous sodium hydroxide solution (5 mL) as starting materials, the title compound (1.5 g, 92%) was obtained as a white solid.

Provenance & Evidence