HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → N-[6-(3-chloro-4-nitrophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Chloro-4-fluoro-1-nitrobenzene | HCID 75017 | — |
| Reactant | N-(6-Hydroxyimidazo[1,2-A]pyridin-2-YL)cyclopropanecarboxamide | HCID 58158532 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | N-[6-(3-chloro-4-nitrophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide | HCID 58158527 | 111.4% |
Reaction Steps
Using N-(6-hydroxyimidazo[1,2-a]pyridin-2-yl)cyclopropanecarboxamide (200 mg, 0.92 mmol), 4-fluoro-2-chloro-1-nitrobenzene (315 mg, 1.79 mmol), dimethyl sulfoxide (4 mL) and cesium carbonate (675 mg, 2.07 mmol), and in the same manner as in Reference Example 101, the title compound (382 mg, 74%) was obtained as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445509B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-6bc485a386b1412b8d5315656160ce23 |
| Source note | uspto-grants-2013_05 |