Ethanol → N-[6-(4-amino-3-chlorophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide

Participants

Reaction Steps

Using N-[6-(3-chloro-4-nitrophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide (300 mg, 0.805 mmol), reduced iron (237 mg, 4.02 mmol), ammonium chloride (430 mg, 8.05 mmol), ethanol (2 mL), tetrahydrofuran (2 mL) and water (0.5 mL), and in the same manner as in Reference Example 105, the title compound (166 mg, 60%) was obtained as a white solid.

Provenance & Evidence