Hydrochloric Acid → HCID 58158523, compound

Participants

Reaction Steps

To a solution of ethyl 1-(4-fluorophenyl)-5-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate (1.2 g, 4.36 mmol) in methanol (12 mL) was added 1N aqueous sodium hydroxide solution (10 mL, 10 mmol), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated, and the obtained residue was diluted with ethyl acetate and water and extracted with water. The aqueous layer was treated with 1N hydrochloric acid (20 mL, 20 mmol), and the precipitate was collected by filtration to give a white solid. The white solid was washed with water to give the title compound (730 mg, 68%).

Provenance & Evidence