Water → HCID 66968897, compound

Participants

Reaction Conditions

Reaction Steps

1-(3,5-Difluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (1.50 g, 6.20 mmol) was suspended in aqueous sulfuric acid solution (98% sulfuric acid 8 mL, water 8 mL), and the mixture was stirred at 120° C. for 10 hr. The reaction solution was cooled to room temperature and poured into water, and the precipitate was collected by filtration. The obtained solid was washed with ethyl acetate to give the title compound (1.00 g, 61%) as a brown solid.

Provenance & Evidence