Hydrochloric Acid → HCID 58158515, compound

Participants

Reaction Steps

To a suspension of methyl 1-(4-fluoro-2-methylphenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate (0.40 g, 1.53 mmol) in methanol (9 mL) was added 2N aqueous sodium hydroxide solution (1.15 mL), and the mixture was stirred at room temperature for 3 hr. 6N Hydrochloric acid (0.5 mL) was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and filtered. The solvent was evaporated under reduced pressure, and the obtained residue was washed with hexane/ethyl acetate (=1/1) to give the title compound (704 mg, 85%) as a yellow solid.

Provenance & Evidence