Water → HCID 58158577, compound

Participants

Reaction Steps

An aqueous solution (98% sulfuric acid 8 mL, water 8 mL) of 1-(4-fluoro-3-methylphenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (1.60 g, 6.60 mmol) in sulfuric acid was stirred at 130° C. for 10 hr. The reaction solution was cooled to room temperature, water was added, and the precipitated solid was collected by filtration. The obtained solid was washed with ethyl acetate to give the title compound (1.00 g, 58%) as a brown solid.

Provenance & Evidence