反应详情

温度

80 °C

To a suspension of N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-3-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide (1.42 g, 2.55 mmol) in ethanol (14 mL) and water (2 mL) was added and dissolved therein 6N hydrochloric acid (510 μL, 3.06 mmol), and the solution was concentrated to a half amount, and left standing for 1 hr. The precipitate was collected by filtration to give white crystals. The white crystals were suspended in ethanol (50 mL) again, 6N hydrochloric acid (205 μL, 1.53 mmol) was added, and the mixture was dissolved at 70° C. The solution was left standing at room temperature for 6 hr. The precipitate was collected by filtration to give a white solid. The white solid (850 mg) was dissolved in ethyl acetate, tetrahydrofuran and saturated aqueous sodium hydrogen carbonate solution, and the mixture was extracted 3 times with ethyl acetate. The combined organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and filtered, and the solvent was evaporated under reduced pressure. The residue was suspended in ethanol (20 mL), heated to 80° C. and dissolved by dropwise addition of 6N hydrochloric acid (358 μL, 2.15 mmol). The solution was allowed to gradually cool to 50° C., and the mixture was stirred overnight. The precipitate was collected by filtration and washed with ethanol to give a white solid. The white solid was suspended in methyl ethyl ketone (10 mL), and the mixture was stirred at 50° C. overnight. The precipitate was collected by filtration and washed with methyl ethyl ketone to give the title compound (590 mg, 39%) as white crystals.

1. additionwas added
2. dissolutiondissolved
3. waitleft
4. filtrationThe precipitate was collected by filtration
5. customto give white crystals
6. dissolutionthe mixture was dissolved at 70° C
7. waitThe solution was left
8. waitstanding at room temperature for 6 hr
9. filtrationThe precipitate was collected by filtration
10. customto give a white solid
11. extractiontetrahydrofuran and saturated aqueous sodium hydrogen carbonate solution, and the mixture was extracted 3 times with ethyl acetate
12. washThe combined organic layer was washed with saturated brine
13. dry with materialdried over anhydrous magnesium sulfate
14. filtrationfiltered
15. customthe solvent was evaporated under reduced pressure
16. temperatureto gradually cool to 50° C.
17. filtrationThe precipitate was collected by filtration
18. washwashed with ethanol
19. customto give a white solid
20. stirringthe mixture was stirred at 50° C. overnight
21. filtrationThe precipitate was collected by filtration
22. washwashed with methyl ethyl ketone