Hydrochloric Acid → HCID 66968569, compound

Participants

Reaction Steps

To a suspension of N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-3-fluorophenyl]-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (480 mg, 0.92 mmol) in methyl ethyl ketone (7 mL) was slowly added 6N aqueous hydrochloric acid solution (4 mL) and then water (4 mL), and the mixture was stirred at 80° C. for 5 min. The mixture was cooled to room temperature and stirred at room temperature for 3 hr. The precipitated solid was collected by filtration, washed with methyl ethyl ketone and dried under reduced pressure to give the title compound (410 mg, 79%) as a white solid.

Provenance & Evidence