Hydrochloric Acid → HCID 66969144, compound

Participants

Reaction Steps

To a suspension of N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-3-fluorophenyl]-2-(4-fluorophenyl)-1,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxamide (400 mg, 0.72 mmol) in methyl ethyl ketone (7 mL) and water (5 mL) was slowly added 6N aqueous hydrochloric acid solution (240 μL), and the mixture was stirred at room temperature for 1 hr. The precipitated solid was collected by filtration, washed with methyl ethyl ketone and suspended in ethanol (5 mL), and the suspension was stirred at 70° C. for 10 min. The solid was collected by filtration, washed with ethanol and dried under reduced pressure to give the title compound (120 mg, 27%) as a white solid.

Provenance & Evidence