p-Toluenesulfonic acid monohydrate → N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-3-fluorophenyl]-6-methyl-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide p-toluenesulfonate

Participants

Reaction Conditions

Reaction Steps

To a suspension of N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-3-fluorophenyl]-6-methyl-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide (650 mg, 1.21 mmol) in ethanol (6.5 ml) was added p-toluenesulfonic acid monohydrate (276 mg, 1.45 mmol) at 70° C. The reaction solution was stirred at 70° C. for 1 hr, and the precipitate was collected by filtration and washed with ethanol to give the title compound (702 mg, 82%) as white crystals.

Provenance & Evidence