Hydrochloride methanol → N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-3-fluorophenyl]-6-methyl-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide hydrochloride

Participants

Reaction Steps

A solution (5 to 10%) of hydrogen chloride/methanol was heated to 50° C., and N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-3-fluorophenyl]-6-methyl-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide (500 mg, 0.93 mmol) was added. The mixture was stirred for 5 min and at room temperature for 30 min. The precipitate was collected by filtration and washed with methanol to give the title compound (420 mg, 79%) as white crystals.

Provenance & Evidence