p-Toluenesulfonic acid monohydrate → HCID 86651403, compound

Participants

Reaction Conditions

Reaction Steps

An ethanol (20 mL) suspension containing N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-3-fluorophenyl]-6-(3-fluorophenyl)-5-methylpyridine-2-carboxamide 1-oxide (833 mg, 1.50 mmol) was heated to 90° C., and p-toluenesulfonic acid monohydrate (314 mg, 1.65 mmol) was added. When the mixture became a uniform transparent solution, the precipitated solid was collected by filtration and washed with ethanol to give the title compound (870 mg, 80%) as a white solid.

Provenance & Evidence