Water → HCID 23071200, compound

Participants

Reaction Steps

To a solution of 2-(methylamino)ethanol (100 g) in ethyl acetate (1000 mL) was added pyridine (222 mL), and added dropwise ethyl chlorocarbonate (240 mL) over 2 hrs under ice-cooling. After the addition, the reaction solution was stirred at room temperature for 18 hrs. To the solution was added water (300 mL), and the ethyl acetate layer was separated. The ethyl acetate layer was washed with 1 N hydrochloric acid (200 mL) and saturated brine (200 mL), and dried over anhydrous sodium sulfate, followed by concentrating under reduce pressure. The residue was distilled under reduce pressure to give title compound (180 g) as colorless fraction having boiling point of 95-100° C. (pressure: 0.1-0.2 mmHg).

Provenance & Evidence