Pyridine → HCID 23093552, compound

Participants

Reaction Steps

To a mixture of tert-butyl 3-hydroxypropylcarbamate (8.00 g) obtained in Reference Synthetic Example 40 and ethyl acetate (50 mL) were added pyridine (4.06 mL) and ethyl chlorocarbonate (5.95 g) under ice-cooling, and stirred at room temperature for 24 hrs. To the reaction solution was added ethyl acetate (100 mL), and washed with water (50 mL), aqueous solution of copper sulfate (30 mL), water (30 mL) and saturated brine (30 mL), followed by drying over anhydrous sodium sulfate. The solution was concentrated under reduced pressure to give title compound as colorless oil (9.31 g).

Provenance & Evidence