Pyridine → HCID 23093559, compound

Participants

Reaction Steps

To a mixture of tert-butyl [2-(2-hydroxyethoxy)ethyl]carbamate (53.93 g) obtained above and ethyl acetate (350 mL) were added pyridine (53.78 mL) and ethyl chlorocarbonate (70.57 g) under ice-cooling, and stirred at room temperature for 96 hrs. To the reaction solution was added ethyl acetate (500 mL), and washed with water (500 mL), aqueous solution of copper sulfate (200 mL), water (300 mL) and saturated brine (300 mL), followed by drying over anhydrous sodium sulfate. The solution was concentrated under reduced pressure to give 2-[2-[(tert-butoxycarbonyl)amino]ethoxy]ethyl ethyl carbonate as colorless oil (93.19 g).

Provenance & Evidence