Lansoprazole → HCID 59769506, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-[(chlorocarbonyl)(phenyl)amino]ethyl acetate (0.58 g) prepared in the same way as in Synthetic Example 25 in tetrahydrofuran (10 mL) were added 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole (0.73 g), triethylamine (0.558 mL) and 4-dimethylaminopyridine (0.024 g), and stirred at 60° C. for 15 hrs. To the reaction solution was added ethyl acetate (30 mL), and washed with water (50 mL) and saturated brine (50 mL), and then, dried over anhydrous sodium sulfate, followed by concentrating under reduced pressure. The residue was purified with flash silica gel column chromatography (eluted with acetone:hexane=1:4, then 3:2). The purified material was crystallized from diethyl ether to give title compound as white solid (0.779 g).

Provenance & Evidence