Iodoethane → HCID 69012300, compound

Participants

Reaction Conditions

Reaction Steps

A four-necked flask was charged with 9.6 g (70 mmol) of p-aminophenetyl alcohol, 38.7 g (280 mmol) of potassium carbonate and 100 ml of monochlorobenzene under argon gas atmosphere, and heated at 120° C. with agitation. To the flask was added dropwise 32.8 g (210 mmol) of ethyl iodide over 5 hours, and after addition, heated for 5 hours with agitation. The reaction solution was cooled to room temperature, diluted with dichloromethane, and washed with water three times. The dichloromethane solution was dried with anhydrous magnesium sulfate followed by solvent removal, and purified by column chromatography on silica gel using mixture solvent of toluene/ethyl acetate (2/1) to give 12.1 g of p-diethylaminophenetyl alcohol (yield=89% by mass).

Provenance & Evidence