Hydrochloric Acid → HCID 178427429, compound

Participants

Reaction Steps

After ethyl 3-[[(1Z)-5,6-dimethyl-1-[[(4-methylphenyl)sulfonyl]imino]-3-oxo-2,3-dihydro-1H-imidazo[5,1-c][1,4]thiazin-8-yl]sulfanyl]propanoate (5.00 g, 10.4 mmol) synthesized in (iii) described above was dissolved in THF (50 ml) and methanol (50 ml), potassium hydroxide (2.74 g, 41.5 mmol) was added to the solution. The mixture was stirred at room temperature for 45 minutes. 1N Hydrochloric acid (42 ml) was added to and mixed with the reaction solution, and the mixture was stirred at room temperature for 30 minutes. The formed precipitate was filtrated, washed with 50% methanol-water and dried to give red powders of the title compound.

Provenance & Evidence